Vulva pagets disease recurrence in rectum

Extramammary Paget's disease of the vulva and anus: EMA is a marker of most normal and neoplastic epithelia but it is also expressed by a variety of mesenchymal and lymphoid neoplasms. Evidence of apocrine derivation. International Journal of Gynecological Pathology ; 29 1: Immunohistochemical markers S and HMB are positive in most cases of melanoma.
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Clin Oncol R Coll Radiol ;7 6: In general, the prognosis for primary extramammary Paget's disease confined to the epidermis is excellent. Conclusions Mammary and extramammary Paget's disease are uncommon intraepithelial adenocarcinomas. Women with anal disease excluded for this review; data from 10 women' analysed. Cytokeratins are water insoluble, fibrous proteins present in almost all epithelia.
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Extramammary Paget's Disease

Gross cystic disease fluid protein GCDFP or BR-2 is present in cyst fluid in fibrocystic disease of the breast and is a marker of apocrine epithelium including normal apocrine glands, apocrine metaplasia in fibrocystic disease, and apocrine carcinomas. Were there no differences between the two groups or differences controlled for, in particular with reference to age, histological grade, performance status, grade of operating surgeon if direct comparison of surgical interventions? Treatment of Paget's disease is complicated by the extension of microscopic disease beyond the visible margins of the lesion, as was observed in our case. Another study has reported that there was no difference in recurrence rate whether or not there were negative surgical margins. Radical surgery with or without adjuvant radiotherapy is advocated for patients with an associated adenocarcinoma. Paget's disease may be primary, arising as an intraepithelial adenocarcinoma, or secondary due to Pagetoid spread of an adjacent or contiguous in situ or invasive tumour. Extramammary Paget's disease of the vulva:
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Transactions of the Pathological Society of London —; A lymphocytic dermal infiltrate is often seen in cases of mycosis fungoides and Paget's disease, and is not a useful discriminant. Br J Dermatol ; It could be assumed that the more radical the surgery, the larger the lesion, but these data are not possible to extract from the papers. In most cases the correct diagnosis can be reached with careful morphological evaluation and the help of a panel of immunohistochemical markers.
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